Biodornaze, Streptokinase and streptodornase are two enzymes often combined in medical treatments to facilitate the breakdown and removal of blood clots and necrotic tissue. Streptokinase is widely known for its role in treating thrombosis (blood clots) by converting plasminogen to plasmin, which breaks down clots. Streptodornase, on the other hand, is used to digest necrotic tissue and reduce viscosity of purulent exudates, aiding in the cleansing of wounds. Together, they are employed in various therapeutic settings, including the management of myocardial infarction (heart attack), deep vein thrombosis, and in the enhancement of wound healing.
Mechanism of Action
Streptokinase works by activating plasminogen to plasmin, an enzyme that dissolves fibrin clots. Streptodornase breaks down the DNA in necrotic tissue, helping to liquefy pus and reduce the viscosity of sputum, facilitating the removal of dead tissue.
Common Uses
Myocardial Infarction: Streptokinase is used to dissolve blood clots in the coronary arteries.
Deep Vein Thrombosis and Pulmonary Embolism: To break down blood clots in the veins.
Wound Healing: Streptodornase with streptokinase is applied to clean wounds by removing dead tissue and liquefying pus.
Dosage Instructions
The dosage of streptokinase for thrombosis typically involves an initial loading dose followed by a continuous infusion, often within the range of 1.5 million IU over 60 minutes for acute myocardial infarction. For wound healing, streptokinase-streptodornase preparations are applied topically, and the amount depends on the wound's size and condition. Always follow the healthcare provider's guidance for specific dosage and administration.
Benefits
Effective in dissolving blood clots and improving blood flow.
Aids in wound healing by cleaning necrotic tissue and reducing infection risk.
Can significantly improve outcomes in acute myocardial infarction and thrombotic conditions.
Potential Side Effects
Bleeding complications, including hemorrhage.
Allergic reactions, sometimes severe.
Nausea and vomiting.
Fever and chills.
Low blood pressure.
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