Mechanism of Action Tadaflo, Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing the muscles of the blood vessels, improving blood flow to certain areas of the body. In erectile dysfunction, tadalafil helps achieve and maintain an erection by enhancing blood flow to the penis during sexual stimulation. For BPH, it relaxes muscles in the bladder, easing the symptoms of ..