Mechanism of Action Imipramine HCl Tab, Imipramine is a tricyclic antidepressant (TCA) that works by increasing the levels of certain neurotransmitters in the brain, primarily serotonin and norepinephrine. It does this by inhibiting their reuptake, which helps improve mood and alleviate symptoms of depression and anxiety. Common Uses Imipramine is commonly prescribed for several conditions: Majo..