Trajenta, Linagliptin is a medication used primarily in the treatment of type 2 diabetes. Mechanism of Action Linagliptin is part of a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the levels of incretin hormones in the body. Incretins help to regulate blood sugar by increasing insulin production in response to meals and decreasing the amount of glucos..