Daxas, Roflumilast is a medication primarily used in the treatment of severe chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, particularly for those who have experienced frequent exacerbations. It functions as a selective inhibitor of the enzyme phosphodiesterase-4 (PDE4), playing a crucial role in reducing inflammation in the lungs and improving airflow.
Mechanism of Action
Roflumilast inhibits the enzyme phosphodiesterase-4 (PDE4) found in lung tissue. PDE4 plays a significant role in the process of inflammation. By inhibiting this enzyme, roflumilast reduces the release of pro-inflammatory substances, thereby decreasing inflammation and relaxing the airways in the lungs. This leads to improved breathing and reduced frequency of COPD exacerbations.
Common Uses
Chronic Obstructive Pulmonary Disease (COPD): Specifically for individuals with severe COPD who have a history of exacerbations.
Dosage Instructions
The recommended dosage of roflumilast is 500 micrograms (mcg) taken orally once daily. It can be taken with or without food. It's important to follow the healthcare provider's instructions precisely and not to adjust the dose without consulting them.
Benefits
Reduces the risk of COPD exacerbations.
Improves lung function and airflow.
Can be used as an add-on therapy to other COPD treatments to enhance breathing capacity.
Potential Side Effects
While roflumilast is generally well-tolerated, some individuals may experience side effects, including:
Weight loss.
Diarrhea.
Nausea.
Headache.
Insomnia.
Rare but more serious side effects can include psychiatric symptoms such as depression and suicidal thoughts.
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#StopCOPD
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