Enalapril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the management of hypertension (high blood pressure) and heart failure. By inhibiting the action of ACE, enalapril helps relax blood vessels, thereby lowering blood pressure and improving blood flow. This effect not only helps to manage hypertension but also reduces the workload on the heart in patients with heart failure.
Mechanism of Action
Enalapril works by inhibiting the angiotensin-converting enzyme, which is involved in the production of angiotensin II. Angiotensin II is a substance in the body that causes blood vessels to narrow, increasing blood pressure. By blocking the production of angiotensin II, enalapril allows blood vessels to relax and widen, leading to lower blood pressure and improved heart function.
Common Uses
Hypertension: To control high blood pressure.
Heart Failure: To treat symptomatic heart failure, often in combination with other medications.
Left Ventricular Dysfunction: To improve survival after a heart attack.
Dosage Instructions
The starting dose for hypertension is usually 5 mg once daily, with maintenance doses typically ranging from 10 to 40 mg daily, depending on the patient's response to the medication. For heart failure, dosages may vary, and treatment should be started under close medical supervision. It's important to follow your healthcare provider's recommendations regarding dosage and to have your blood pressure and kidney function monitored regularly.
Benefits
Effective in lowering high blood pressure.
Helps in managing heart failure and improving heart function.
Can reduce the risk of stroke and heart attack in patients with hypertension.
Potential Side Effects
While enalapril is generally well-tolerated, some individuals may experience side effects, including:
Cough.
Dizziness.
Fatigue.
Nausea.
Hyperkalemia (high potassium levels in the blood).
Rare but serious side effects include angioedema (swelling of the deep layers of the skin) and kidney impairment.
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