Rufapin, Rupatadine is a second-generation antihistamine and PAF (platelet-activating factor) antagonist used primarily to treat symptoms of allergic rhinitis and urticaria (hives). Unlike first-generation antihistamines, rupatadine is less likely to cause sedation because it does not readily cross the blood-brain barrier.
Mechanism of Action
Rupatadine works by blocking the action of histamine at the H1 receptor, which prevents the typical symptoms triggered by allergies (such as sneezing, itching, and runny nose). Additionally, it acts as an antagonist to the platelet-activating factor (PAF), which is involved in allergic responses, further helping to reduce inflammation and allergic symptoms.
Common Uses
Allergic Rhinitis: Helps relieve symptoms like sneezing, itchy and runny nose, and eye irritation.
Chronic Urticaria: Effective in reducing the frequency and intensity of hives and associated itching.
Dosage Instructions
Rupatadine is typically administered once daily:
Adults and Children 12 Years and Older: The recommended dose is 10 mg once daily.
Children 2 to 11 Years Old: Dosing may vary, often based on body weight, and should be determined by a healthcare provider.
It can be taken with or without food, but consistency in taking it with respect to meals helps maintain steady absorption and effectiveness.
Benefits
Provides effective relief from the symptoms of allergic rhinitis and urticaria without the sedative effects commonly associated with older antihistamines.
Has anti-inflammatory properties that help reduce the severity of allergic reactions.
Offers once-daily dosing, which is convenient for patients.
Potential Side Effects
While rupatadine is generally well-tolerated, some individuals may experience side effects such as:
Headache.
Dizziness.
Fatigue.
Dry mouth.
In rare cases, increased appetite and weight gain.
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