Mechanism of Action Eliquis Tab, Apixaban is an oral anticoagulant (blood thinner) that belongs to a class of drugs known as direct oral anticoagulants (DOACs). It works by inhibiting Factor Xa, an enzyme crucial in the blood clotting process. By blocking Factor Xa, apixaban reduces the formation of blood clots, helping to prevent conditions such as stroke, deep vein thrombosis (DVT), and pulmon..